International Journal of Pediatric Dermatology

A Severe Case of Pediatric Linear IgA Bullous Dermatosis

2025-12-12T18:56:22+00:00

Linear IgA bullous dermatosis (LABD) is a rare immune-mediated subepidermalmblistering disease, most commonly affecting children between 4 and 5 years of age. Although generally self-limiting, some cases present diagnostic and therapeutic challenges.

We report an 8-year-old boy who presented at age 5 with disseminated pruritic bullous lesions. Initial direct immunofluorescence was inconclusive, and diagnosis was confirmed only three years later upon repeat biopsy demonstrating linear IgA deposition at the basement membrane zone. The clinical course was complicated by recurrent secondary infections, drug-induced hepatitis from dapsone overdose, cyclosporine-induced disease aggravation, and treatment non-adherence. Disease control was ultimately achieved with dapsone and corticosteroids.

This case highlights the importance of repeat biopsy when clinical suspicion persists despite inconclusive findings, careful drug monitoring, and comprehensive caregiver education. A multidisciplinary approach is essential for managing severe pediatric LABD.

Successful Repigmentation of Extensive Pediatric Vitiligo with Oral Upadacitinib: A Case Report

2026-04-13T14:35:11+00:00

Generalized vitiligo in children is challenging to treat and often demonstrates an incomplete response to conventional therapies. In this case report, a 12-year-old boy with generalized vitiligo involving 75% of the body surface area had failed nearly two years of treatment with home narrowband UVB phototherapy, topical tacrolimus, topical corticosteroids, and pulsed oral dexamethasone. Oral upadacitinib at a dose of 30 mg daily was initiated in August 2025. Significant repigmentation was observed within three months, with complete clearance of facial lesions and marked improvement across the trunk and extremities. Treatment with oral upadacitinib as monotherapy allowed for the complete discontinuation of all topical agents and phototherapy. This case highlights the potential role of oral Janus kinase inhibitors as an effective therapeutic option in selected pediatric patients with refractory generalized vitiligo.

The Burden of Tinea Capitis in Paediatric Refugee Populations: A Systematic Review

2025-12-23T15:08:40+00:00

Tinea capitis (TC) is a dermatophytic fungal infection that infects the scalp predominantly in children resulting in both physical and psychosocial impacts. Refugee children have increased risk factors for infection due to factors related to overcrowding, sharing of grooming items or reduced sanitation access during transit and decreased access to healthcare services. This systematic review examined the burden of tinea capitis in paediatric refugee populations until September 2025. Of 449 studies screened, 6 were included for review. Four studies were from the Middle East region and two studies were from Australia. Overall, our study highlights the limited refugee-specific evidence on Tinea capitis in paediatric populations but published studies span over two decades and reveal a lack of recent, systematic epidemiological data. Higher infection rates were found in younger children and males, particularly among those of African descent. Rates of infection ranged from 0.43–1.06% in the Middle East to 9–15% in Australia. Trichophyton violaceum was the predominant pathogen with an increasing burden among displaced children. Strengthened surveillance and integration of fungal screening through skin checks into refugee health assessments are needed to improve early detection, treatment, and reduce health inequity.