International Journal of Pediatric Dermatology

Acrokeratoelastoidosis: case report

2024-03-10T20:31:08+00:00

Acrokeratoelastoidosis (AKE) is a rare, benign keratoderma that presents as keratotic papules on the borders of palms and soles and frequently involves the dorsum of hands and feet. In most cases it is inherited in an autosomal dominant fashion but also sporadic forms have been reported. Its pathogenesis remains unclear. Histopathology shows the presence of a reduced number of thick and fragmented elastic fibers in the dermis (elastorhexis). Various forms of treatments have been attempted with modest or poor results.

We present an inherited case of AKE in an 14-year-old girl with papular elements simmetrically spread to the knuckles of the fingers from the age of eight.

Pigmented purpuric dermatosis in pediatric patients

2024-03-22T02:03:33+00:00

Pigmented purpuric dermatoses correspond to chronic, idiopathic and self-limited diseases. They are rare, especially in the pediatric population. These conditions manifest as purpuric lesions with variable pigmentation as a result of erythrocyte extravasation and hemosiderin deposits in the superficial dermis. They may have a significant impact on patients’ quality of life. There is no standardized treatment, so it must be evaluated on a case-by-case basis to define the management, considering risk and benefits involved.

Probable griseofulvin-induced morbilliform exanthem: a case report

2024-04-22T07:51:55+00:00

The administration of drugs in average doses for medical purposes may cause cutaneous and mucosal manifestations known as cutaneous adverse drug reactions, which are neither expected nor desired. These skin eruptions may be seen in both mild and severe forms and among them, morbilliform exanthems should be pointed out as these can be caused by the intake of drugs usually beta-lactam antibiotics; however, they can occasionally be induced by other drugs. Among these, as seen in the 10-year-old male patient we present, some cases have been reported originating from the use of griseofulvin, an antimycotic widely used to treat mycoses due to Microsporum canis. The best therapeutic approach, and sometimes the only one, is the rapid suspension of the causative drug, which is usually enough to resolve the situation in a few days. In the case of our pediatric patient, the decision was taken to therefore discontinue the drug. Once the condition was overcome, it was concluded to refer him to the Division of Allergy and Immunology in the hospital as an essential aspect of medical practice in order to better specify our presumptive diagnosis of drug hypersensitivity.

Epidermolytic keratinocytic nevus as an expression of cutaneous mosaicism

2024-04-08T14:48:59+00:00

Epidermolytic ichthyoses are genetic disorders of keratinization. The epidermolytic keratinocytic nevus present mutations in a cutaneous mosaicism pattern.

We present a 6-year-old girl with epidermolytic keratinocytic nevus, whose diagnosis was only possible after skin biopsy.