Journal of Applied Cosmetology

Future Challenges of Vitamin D Deficiency: The Impact of Systemic Vitamin D Therapy on Serum Levels and Skin Diseases

2025-04-01T21:12:20+00:00

In recent years, research on the role of vitamin D in skin diseases has grown, revealing its dose-dependent effects on cell function and its immunomodulatory, antioxidative, and cytoprotective properties. These findings have expanded their use in dermatology. However, the rising incidence of deficiency, linked to reduced sun exposure from indoor lifestyles and cultural practices, underscores the need for further investigation and therapeutic strategies. To review key insights on the systemic use of vitamin D in common immunomodulatory skin diseases, beyond its well-established topical applications. The electronic research of the literature included three databases: MEDLINE, Cochrane, and Google Scholar, as well as other available literature sources. Decreased serum vitamin D levels are observed in psoriasis, vitiligo, and alopecia areata. Systemic vitamin D therapy has shown clinical improvement in psoriasis, vitiligo, and atopic dermatitis, with limited but promising evidence in alopecia areata. It may play a role in managing acne vulgaris, though long-term data remain insufficient. The effects of systemic vitamin D analogs in the clinical treatment of many skin diseases are promising, but further clinical studies are needed.

Skin Quality and Aging: New Frontiers in Hydration, Firmness, and Cellular Regeneration

2025-04-09T11:01:33+00:00

Skin aging involves a progressive decline in hydration, firmness, and regenerative capacity (1). The objective of this study is to evaluate the clinical effects and elucidate the mechanism of action of a novel biostimulator formulation composed of fragmented hyaluronic acid, choline, and essential amino acids on key indicators of skin quality, including hydration, dermal firmness, and cellular regeneration. The study further seeks to position this formulation as a low-inflammatory alternative to conventional aesthetic treatments that rely on controlled tissue damage, contributing to the development of biocompatible, physiologically integrative approaches in regenerative aesthetics. This study seeks to establish new therapeutic frontiers in aesthetic medicine, where biocompatibility, physiological biostimulation, and preservation of the cellular environment become pillars of healthy and conscious aging. Twenty patients aged between 35 and 65 years were treated over a 12-week period. Skin firmness was measured using cutaneous elastometry. Subjective and biometric evaluations were conducted. A 28% improvement in skin firmness was observed through elastometry (p<0.05). Patients reported significant improvements in hydration, tone, and luminosity. Biostimulatory solution for facial rejuvenation has illustrated the effect on physiological changes that mitigate facial aging.

A Comparative Case Study on Echographic Behaviour of Selected Soft Tissue Fillers

2025-05-05T07:13:01+00:00

Soft tissue fillers, whether based on cross-linked hyaluronic acid (HA) or other ingredients like calcium hydroxyapatite (CaHA), have been developed for long-term facial volume restoration. This case study aims to assess the behaviour, efficacy, durability, tolerability, integration, and degradation of selected soft tissue fillers in treating soft tissue deficits. Nine subjects were randomly divided into three groups, each receiving different soft tissue dermal fillers. Symmetrically, 0.5 ml of product was administered per side subcutaneously in the zygomatic arch area using a sterile 22G cannula via puncture with a sterile 21G needle. Patients underwent treatment at baseline (week 0), with no optional touch-ups allowed. Assessments were conducted at month 1, 3, and 6 using the HF-USG imaging. High-frequency ultrasonography (HF-USG) imaging of the zygomatic arch area was performed at all visits. Adverse events (AEs) were monitored and recorded. Analysis of HF-USG images indicated superior properties for PEGDE cross-linked acid, with no reported adverse events. All participants demonstrated aesthetic improvement, with projection and volumetric effects varying among the filler types. The study underlines the importance of filler selection and anatomical knowledge in achieving desired outcomes. High-frequency ultrasound offers valuable insights into filler behaviour and tissue response. Further research with larger sample sizes is warranted to validate these findings and explore additional parameters.

Case Study on a Multi-Layer Approach to Skin Rejuvenation: Effects of Energy-Based Devices and Injectable Biostimulatory Therapies

2025-05-28T10:31:58+00:00

Achieving smooth, healthy-looking skin is a common aesthetic goal across all age groups. This study assessed the effectiveness of a novel protocol combining non-crosslinked hyaluronic acid (HA), hydro-exfoliation, infrared technology and non-ablative fractional 1470 nm laser to enhance skin quality parameters. This case report included participants aged 43 and 58 years, both in good general health but exhibiting signs of skin atrophy or aging in the face or neck area. On Day 0, subjects underwent mesotherapy injections with non-crosslinked HA (18 mg/mL), supplemented with 0.01% calcium hydroxyapatite, glycine, and l-proline, administered at depths of 0.5 to 4 mm. On Day 7, a hydro-exfoliation and infrared treatment was performed, followed by a session with a non-ablative fractional 1470 nm laser. Skin quality improvements were visually assessed through comparative photographic analysis taken before treatment and four weeks post-procedure. The comparison revealed enhancements in wrinkle reduction, pore size, skin texture, and overall firmness. All treatments were well tolerated. In conclusion, the combination of non-crosslinked HA mesotherapy, hydro-exfoliation, infrared technology, and non-ablative fractional laser led to noticeable improvements in multiple skin quality parameters across a broad age range. While the study highlights the cosmetic benefits of this approach, further research is needed to comprehensively evaluate the long-term safety profile of these treatments, as the current methodology was not specifically designed for safety assessment.

Application of Non-Injection Redermalization in Cosmetic Procedures for Aging Facial Skin and Effects on Human Well-Being

2025-06-05T12:21:19+00:00

Skin aging not only affects physical appearance but also causes psychological stress, which affects human well-being. Therefore, many anti-aging strategies have been developed and proposed, especially in recent times, as the importance of aesthetics, interest in maintaining a youthful skin appearance, and the growth of the elderly population are driving the demand for skin regeneration and rejuvenation products and services. One of the fast-growing antiaging cosmetic procedures is redermalization, which can be defined as the rejuvenation, restoration or regeneration of aging skin, which is supported by the acids used during redermalization procedures (a combination of hyaluronic acid and succinic acid), which activate fibroblasts responsible for collagen fiber synthesis and the production of growth factors such as TGF-β, improve microcirculation, and stimulate skin renewal and tissue reconstruction processes. The study is conducted to determine the effect of non-injection redermalization cosmetic procedures on aging skin and human well-being, based on a specific case study. In the research, the aging skin problem of the study participants was defined and considered a separate case, studied to develop a comprehensive, holistic understanding of the specific phenomenon in the given context. The study results showed improvement in the specific participant’s facial skin aging issues, with decreased dehydration and wrinkle depth, and an overall improvement in the condition and appearance of the facial skin. The research participant felt rested, positive, and self-satisfied. Social characteristics also changed; the research participant felt able to control her time and achieve her goals, which improved communication with work colleagues, friends, and family. Non-injectable redermalization cosmetic procedures, based on a single, specific case study, have a positive effect on aging skin and human well-being.

Layered Biorevitalization: the sandwich technique combined with Neauvia Hydro Deluxe for enhanced skin quality

2025-08-04T12:11:34+00:00

Personalized treatment based on an innovative approach to physiological skin regeneration targets multiple mechanisms of aging. This strategy helps to effectively address aesthetic concerns and optimize therapeutic outcomes. This report presents preliminary observations on the clinical use of non-crosslinked hyaluronic acid enriched with glycine and L-proline for facial skin rejuvenation and regeneration. Aging is a complex, multilevel process that affects various layers of the skin. It involves both structural and functional changes in the epidermis, as well as in the superficial and deep dermis. These changes include decreased collagen and elastin production, reduced hydration, diminished fibroblast activity, and thinning of the extracellular matrix, all of which contribute to visible signs of aging such as laxity, fine lines, and volume loss. These findings support the use of personalized, multilayered biorevitalization in aesthetic practice.