Journal of Applied Cosmetology

Biological basis of the aesthetic and rejuvenating effects in the skin after the application of the compressive microvibration Endospheres.

Sheila Veronese — 2024-06-24

Compressive microvibration is a type of stimulation patented as Endospheres therapy. The stimulation, through Endospheres, applied externally to the skin surface, causes changes in the physiological and functional structure of tissues underneath the epidermis, including adipose tissue. Cyclic mechanical stress, induced by this therapy with its particular compressive microvibration, modifies the normal cell cycle of adipose tissue and promotes tissue remodelling due to the activation of the abundantly present mesenchymal-derived stem cells. In this study, a literature revision was performed to elucidate the mechanisms through which the repetitive, cyclic or modulated/ordered mechanical input of Endospheres, which results in harmonic compressive microvibrations, can have beneficial effects on the skin and all subcutaneous tissues up to the muscles, improving rejuvenation, tissue repair, vascularization and macro-organization. It was possible to formulate the hypothesis that the ordered frequency and oscillatory dynamics can completely change the chaotic and oscillatory patterns of mitochondria alongside the endoplasmic reticulum membrane in a recently discovered complex known as mitochondria-associated endoplasmatic reticulum membrane complex or mitochondria-associated endoplasmatic reticulum membrane. Analyzing the biochemical and physical characteristics of these structures, it was assessed that the nature of the benefits of the Endospheres stimulation of tissues could include three different origins: mechanical, linked to the transfer of mechanical inputs; biophysical, related to the chaotic biology of mitochondria, the generation of sinusoidal waves and the generation of piezoelectric forces; and biochemical, linked to the sensory function of adipose tissue. All these forces are discussed in detail.

Generative medicine - towards a systematization of mechanical compressive microvibration treatments in aesthetic, regenerative, and anti-aging medicine: theoretical bases, tissue targets, and classification

Sheila Veronese — 2024-09-05

Regenerative medicine is the new frontier of medicine, with a high degree of translationality, which involves different medical specializations, engineering, and information technology. It has as a target the human tissues. Lesions not yet irreversible become treatable. Aging can be re-discussed. In fact, preventive treatments arise; among these, the minimally invasive are particularly interesting. Mechanical treatments are included in the latter. A precise new classification of mechanical treatments was performed in this study. In particular, a detailed analysis was performed relating to mechanical compressive microvibration therapy. Both the tissue target and the bio-physical effects of this treatment were evaluated. All the aspects were analyzed to correlate theoretical expectations with the preliminary results of a research project. The regenerative effects appeared clear, and the absence of tissue damage was remarkable. For these reasons, mechanical compressive microvibration therapy can be included in the typology of mechanical regenerative therapies.

Immune system triggers as a factor for the formation of foreign body granuloma after hyaluronic acid fillers treatment.

Radina Denkova — 2024-06-07

Injections of hyaluronic acid dermal fillers are minimally invasive cosmetic procedures that in general are considered safe. However, a lot of complications have been reported for the last couple of years. The formation of foreign body granuloma is a rare side effect which usually happens weeks to months after the injection of soft tissue fillers and is one of the most challenging when it comes to management. This study aims to report a case of foreign body granuloma formation after full face treatment with 12 ml of hyaluronic dermal fillers. A short overview of the main factors influencing granuloma formation and a treatment protocol are also presented.

Redox homeostasis and pH monitoring: a step forward to personalized medicine and dermatology

T. Lotti — 2024-08-26

Skin is continually subjected to various environmental stressors, such as pollution, UV rays, and other oxidative damage factors. It is obligatory to ascertain the exact importance of redox status and ROS indicators, which may be assessed in diverse physiological fluids and tissues. Reactive oxygen species (ROS) can cause lipid peroxidation, which can compromise the integrity and functionality of skin cells by degrading membrane lipids. This may compromise the skin barrier, making the skin more prone to infections and environmental irritants, increasing water loss and dryness. Collagen in the dermis can covalently link to malondialdehyde (MDA), a byproduct of lipid peroxidation generated by oxidatively damaged skin lipids, to form MDA-collagen adducts. Several types of skin cancer are associated with a heightened vulnerability of DNA purine and pyrimidine bases to oxidative damage and altered DNA repair capacity (DRC). Damage from ROS may cause hyaluronate to become less viscous, which increases its susceptibility to degradation. Elastin hydrodynamic radius decreased the rate of self-assembly in response to ROS. Alterations in redox homeostasis can lead to various diseases and conditions, including vitiligo, actinic keratosis, psoriasis, contact dermatitis, systemic sclerosis, the onset of wrinkles, and skin aging. The most recent formulations' capacity to improve pH and Redox simultaneously can be attained by carefully selecting proposed antioxidant formulations. The combination of modern preparations is currently available and should be used in accordance with the suggested guidelines.