Journal of Applied Cosmetology <p><sub>The JOURNAL OF APPLIED COSMETOLOGY is an international journal dedicated to publishing original papers, reviews and other material which represent a useful contribution to research on the skin and on cosmetics. It is aimed at cosmetic chemists, dermatologists, microbiologists, pharmacists, experimental biologists, toxicologists, plastic surgeons, and all other scientists working on products which will come into contact with the skin and its appendages. The Journal is published every 6 months in English. It is distributed to cosmetic chemists, dermatologists, plastic surgeons, medical and pharmaceutical schools, medical libraries, selected hospitals and research institutions through the world, and by subscription to any other interested individuals or organizations. Statements and opinions expressed are personal to the respective contributors and are not necessarily endorsed by the Editor(s), Advisers, Publishers of Distributors of this Journal.</sub></p> World Health Academy Publishing House en-US Journal of Applied Cosmetology 0392-8543 Cosmetic Prosthodontics Damiano Mucchi Copyright (c) 2024 Journal of Applied Cosmetology 2024-01-16 2024-01-16 42 1 64/70 64/70 10.56609/jac.v42i1.316 Use of Botulinum Toxin in Dermatology <p>Botulinum toxin (BoNT), initially approved for strabismus in 1989, has expanded its therapeutic applications into dermatology. This review assesses BoNT’s potential role in treating various dermatological conditions, including Hidradenitis Suppurativa (HS), rosacea, androgenetic alopecia, plaque psoriasis, and primary hyperhidrosis. Studies suggest BoNT’s efficacy in HS, with reductions in inflammation and pain, yet controlled trials are necessary for conclusive evidence. In rosacea, BoNT injections mitigate erythema, but mechanistic understanding remains incomplete. Androgenetic alopecia studies reveal increased hair density following BoNT injections, possibly through dermal papilla modulation and scalp muscle relaxation. BoNT shows promise in plaque psoriasis, likely by mitigating neurogenic inflammation. In primary hyperhidrosis, BoNT significantly reduces sweat production and severity, offering a viable second-line treatment. Despite BoNT’s potential, its use requires caution due to associated risks. Dermatologists must balance on-label and off-label applications for optimal patient outcomes. While existing evidence underscores BoNT’s therapeutic potential, rigorous clinical trials are warranted to establish safety and efficacy definitively. Continued research is imperative to refine BoNT therapy and expand its dermatological applications. This review highlights the need for ongoing investigation and consensus-building to maximize BoNT’s benefits in dermatology.</p> Marcelina Kądziela Copyright (c) 2024 Journal of Applied Cosmetology 2024-04-17 2024-04-17 42 1 60/63 60/63 10.56609/jac.v42i1.317 Cleaning of the blood vessels <p style="text-align: justify;"><strong>&nbsp; The integrity of blood vessels is critical to vascular homeostasis, whose disruption is involved in atherosclerosis (AS), causing stroke and myocardial infarction. Therefore, detecting early AS is essential to avoid severe complications. </strong><strong>An arteriograph is the best device for detecting early AS by measuring the rigidity of the blood vessels. To date, there are no safe and effective treatments to clean the blood vessels from lipid accumulation and calcium deposition, which are involved in the onset of AS. For this purpose, we have developed a 4-weeks non-pharmacological protocol, consisting of intravenous laser blood irradiation, injections of glutathione and carnosine, and oral supplementation with phosphatidylcholine, aimed at patients with risk factors for early AS. We observed a significant amelioration of lipids parameters and PWVao, an indicator of the existence of asymptomatic AS, confirming the efficacy of our protocol. Besides, all other health issues must be improved. </strong></p> Dinko Kaliterna Q. Zhu I. Bizic Copyright (c) 2024 Journal of Applied Cosmetology 2024-02-26 2024-02-26 42 1 15/21 15/21 10.56609/jac.v42i1.322 Ultrasonographic Picture Of The Skin And Subcutaneous Tissue In The Treatment Of Cellulite Using The Compressive Microvibration® <p style="text-align: justify;"><strong>In recent years, the demand for non-invasive methodologies in aesthetic medicine for treating localized adiposity, cellulite, and sagging skin has increased significantly, particularly the demand for massage techniques with mechanical vibrations. The aim of the present study is to evaluate the effectiveness of Compressive Microvibration® in reducing the expression of cellulite and improving skin conditions in women of different ages under ultrasound control during 60 days of observation. A prospective, single-center, nonrandomized study enrolled 27 women with mild to moderate gynoid lipodystrophy, aged 40 to 69 years, who have been subject to twelve sessions of Compressive Microvibration® (Endospheres®). A specialized high-resolution digital ultrasound system, the DUB SkinScanner (tpm GmbH, Germany), has been used to visualize the skin. Also, the sample anthropometric parameters have been measured, the body mass index has been calculated, and photographs have been taken. In the patients included in the study, in all age groups, after complete treatment of Endospheres®, a decrease in BM has been noted, with a reduction of the bitrochanteric and hip circumference. &nbsp;An improvement in the morphological topography of the skin in terms of regularization of skin irregularities, leveling of reliefs, reduction of depressions, and increase in skin elasticity and density has also been recorded. After a cycle of therapy on the anterior surface of the abdomen and the thigh anterior and posterior surfaces, the scannograms revealed a decrease in the thickness of the epidermis at various levels, the resolution of the phenomenon of hyperkeratosis, a compaction of the dermis, and an increase in its homogeneity and echogenicity. The effect obtained was still present during a control examination two months after the conclusion of the treatment. The analysis of the dynamics of ultrasound criteria demonstrated the effectiveness of the Compressive Microvibration® in women with mild to moderate gynoid lipodystrophy to improve their skin conditions and maintain the obtained effect for 2 months of observation without unwanted side complications.</strong></p> Z. Z. Kardashova E. V. Selezneva N. A. Vasilenko I. A. Vasilenko R. Saggini P. A. Bacci Copyright (c) 2024 Journal of Applied Cosmetology 2024-03-13 2024-03-13 42 1 4/14 4/14 10.56609/jac.v42i1.326 Use of bipolar radiofrequency in combination with hyaluronic acid filler in the treatment of vaginal atrophy induced sexual dysfunction in cancer survivors: a case series <p style="text-align: justify;"><strong>Cancer is not only the leading cause of mortality but also has serious negative consequences related to the sexual, mental, and social life not only of the patients themselves but also of their families. Among women who survived cancer, treatment consequences and sexual dysfunctions are serious problems affecting sexual well-being. The aim of this article was to evaluate the effectiveness of the use of non-hormonal bipolar radiofrequency in combination with hyaluronic acid filler in the treatment of vaginal atrophy-induced sexual dysfunction in cancer survivors. We described 3 cases that reported beneficial results with bipolar radiofrequency in combination with hyaluronic acid filler in the treatment of vaginal atrophy-induced sexual dysfunction in cancer survivors. The validated tool, The Female Sexual Function Index (FSFI), before and after treatment was used to assess the progress and effectiveness of the method used. The procedure used for each patient consists of 4 sessions. During the first one, a treatment using bipolar radiofrequency and hyaluronic acid filler injection was performed. The following 3 sessions with intervals – between 3 to 4 days were only RF treatments. Our case series showed that combined therapy of hyaluronic acid and bipolar radiofrequency was effective and significantly improved overall sexual function (FSFI). The treatment turned out to be safe and painless with no side effects.</strong></p> Nabil Elmahdawi Copyright (c) 2024 Journal of Applied Cosmetology 2024-03-08 2024-03-08 42 1 52/59 52/59 10.56609/jac.v42i1.324 Keratoderma climactericum: an under-reported condition successfully treated with an estriol cream <p style="text-align: justify;"><strong>Climacteric keratoderma is a specific cutaneous disorder often underreported, potentially misdiagnosed, or undervalued. Although the pathogenesis remains undetermined, hormonal changes during menopause heavily affect the trophism and normal cellular function of the epidermis and dermis of the palmoplantar regions. We present the case of a 55-year-old woman referred to the Dermatological Clinic of Cagliari for acquired bilateral palmoplantar hyperkeratosis not responding to common topical treatments. Based on the medical history, clinical appearance of the lesions, and laboratory tests, keratoderma climactericum was diagnosed, as confirmed by histopathological examination. An overlap with allergic contact dermatitis was also detected through patch testing, and its synergic effect contributed to the perpetuation of the dermatosis on the hands. A daily high-potency corticosteroidal topical therapy, combined with a 50% urea-based cream at night, was only partially effective. However, adding estriol-based cream at a concentration of 0.125% led to a significant clinical improvement. Climacteric keratoderma is an acquired condition that deserves further clinical trials to assess topical hormonal treatment protocols, as the current approach is largely empirical. </strong></p> Alice Tatti Brunella Conti Marialuisa Corbeddu Martina Uda Giovanni Deriu Andrea Di Buduo Jasmine Anedda Luca Pilloni Caterina Ferreli Laura Atzori Copyright (c) 2024 Journal of Applied Cosmetology 2024-03-22 2024-03-22 42 1 40/44 40/44 10.56609/jac.v42i1.329 Case report: temporal hollowness augmentation with PEGylated fillers <p style="text-align: justify;"><strong>The use of fillers based on hyaluronic acid in correcting deficits in the upper part of the face, especially in the temporal area, can significantly improve the balance and appearance of the face. Such a procedure, apart from unquestionable aesthetic advantages, carries significant risks, including contour irregularities, vascular occlusion, skin necrosis, hair loss, blindness, stroke</strong><strong>,</strong><strong> and non-thrombotic pulmonary embolism. </strong><strong>To</strong><strong> increase the safety and precision of </strong><strong>the </strong><strong>volumization of the temple area, the technique of administration of the preparation</strong><strong>,</strong><strong> as well as the product itself</strong><strong>,</strong><strong> should be carefully selected.</strong></p> Raquel Fernández de Castro Isalguez Copyright (c) 2024 Journal of Applied Cosmetology 2024-04-04 2024-04-04 42 1 45/51 45/51 10.56609/jac.v42i1.332