Combination of PRP, chemical peeling and IPL in controlling Acne – a multimodality approach

2024-10-15T09:59:05+00:00

A common skin condition, Acne Vulgaris, is a disease affecting the pi-losebaceous glands. The common occurrence is on the face, back, and arms, but it can also be present in other areas. The problem with treating acne is the long-term treatment, leading to less compliance and frustration among patients. There are various systemic and topical treatments avai-lable for treating acne. The problem is the long-term treatment and slow results leading to a lack of patient adherence. The other concern is the side effects of these medicines. Various clinical options are being used as an adjunct to other medications or as monotherapy. Platelet-rich plasma is an autologous concentration of platelets. The growth factors released from activated platelets can control the inflammatory process, angioge-nesis, and wound healing. Chemical peels are exfoliative agents that can regenerate healthy skin and have been used to treat acne for decades. In-tense pulse light has an antibacterial ability and controls the erythema. The study evaluated the efficacy of combining PRP, chemical peeling, and IPL in noncompliant patients with topical or oral medication. A com-bination of these three modalities was done in 5 patients in whom tole-rability or compliance with other medications was an issue. There was a significant improvement in all 5 patients. The satisfaction rate of the patients was good. A combination of modalities is an effective and safe way to handle acne. Alone or combined with topical or oral medication, a multimodality treatment in clinics can help patients fight acne better. Larger, randomized clinical trials are needed to support these findings.

Skin Rejuvenation with Hyaluronic Acid and Sirtuin-1 Activa-tors (Nicotinamide Adenine Dinucleotide and Resveratrol): A Comparative Clinical Study of Microneedling and Injection Delivery

2025-06-11T11:04:34+00:00

Skin aging results from both intrinsic and extrinsic factors, leading to a decline in hydration, elasticity, and the structural integrity of the skin. A novel skinca-re formulation has been developed to address these changes using five syner-gistic components: dual molecular weight hyaluronic acid (HA), Nicotinamide Adenine Dinucleotide (NAD⁺), liposomal resveratrol, biomimetic peptides, and mannitol. These actives collectively target hydration, oxidative stress, col-lagen synthesis, and mitochondrial function. Central to the formulation is the activation of Sirtuin-1 (SIRT1), a longevity-associated gene involved in DNA repair and cellular resilience (1), enhanced through the synergistic action of NAD⁺ and resveratrol. This clinical study was randomized and evaluated the efficacy of the formulation delivered through two methods: micronee-dling, consistent with the product’s authorized cosmetic use, and a five-point injection technique, representing an off-label application, in a total of 20 pa-tients. The off-label administration was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and received prior approval from an ethics committee. Parameters assessed include hydration, elasticity, wrinkle reduction, and patient satisfaction. Results showed a 55% increase in hydration and a 42% improvement in elasticity for the injection group, compared to 38% and 25%, respectively, for the microneedling group. Injection allows deeper and more targeted delivery of active compounds into the dermal-subdermal junction, which may enhance bioavailability and the-rapeutic effects compared to the more superficial diffusion associated with microneedling.

Journal of Aesthetic and Regenerative Medicine.

Combination of PRP, chemical peeling and IPL in controlling Acne – a multimodality approach

Skin Rejuvenation with Hyaluronic Acid and Sirtuin-1 Activa-tors (Nicotinamide Adenine Dinucleotide and Resveratrol): A Comparative Clinical Study of Microneedling and Injection Delivery