Probable griseofulvin-induced morbilliform exanthem: a case report

Abstract

The administration of drugs in average doses for medical purposes may cause cutaneous and mucosal manifestations known as cutaneous adverse drug reactions, which are neither expected nor desired. These skin eruptions may be seen in both mild and severe forms and among them, morbilliform exanthems should be pointed out as these can be caused by the intake of drugs usually beta-lactam antibiotics; however, they can occasionally be induced by other drugs. Among these, as seen in the 10-year-old male patient we present, some cases have been reported originating from the use of griseofulvin, an antimycotic widely used to treat mycoses due to Microsporum canis. The best therapeutic approach, and sometimes the only one, is the rapid suspension of the causative drug, which is usually enough to resolve the situation in a few days. In the case of our pediatric patient, the decision was taken to therefore discontinue the drug. Once the condition was overcome, it was concluded to refer him to the Division of Allergy and Immunology in the hospital as an essential aspect of medical practice in order to better specify our presumptive diagnosis of drug hypersensitivity.