Embelin-A natural potential cosmetic agent

Authors

  • N. Radhakrishnan Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India
  • V. Kavitha Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India
  • STK. Raja Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India
  • A. Gnanamani Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India
  • A.B. Mandai Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India

Keywords:

Embelia ribes, Embelin, Hemolytic activity, Tyrosinase activity, DOPA auto-oxidation activity

Abstract

Embelia ribes one of the lndian traditional medicina] plant, has been used as a cosmetic agent to cure skin disorders for centuries. E.ribes is used especially for dyeing hairs, good pimple remover, treating acne, treating carbuncle infections , treating viti ligo and leucoderma. E. ribes berries contain a quinone derivative embelin (2,5-dihydroxy -3-undecyl,l ,4- benzoquinone), has a wide spectrum of biological activities, such as antioxidant, antitumor, anti-inflammatory and analgesie, antihelmintic, antife1tility and antimicrobial. Quinone derivatives and the analogs; Ubiquinone (Coenzyme Q10), ldebenone, Arbutin and Hydroquinone are well-known for cosmetic applications. In the present study, embelin from E.ribes berries of Indian origin was extracted and characterized by UV and FTIR analyses. Hemolytic, tyrosinase and DOPA auto-oxidation assays were also carried out. About 1.9± 0.1 gram of pure embelin was obtained from 100 gram of powdered berries (E.ribes). The characteristics studies reveal the properties are on par with the standard embelin received from Sigma (USA) . The halfmaximal effective concentration (ED50) of embelin to cause hemolysis was found as 109± O.I μg/ml. The tyrosinase inhibitory activity of embelin was nit and the DOPA auto-oxidation activity was observed up to 350 μg /ml concentration. Thus the embelin finds, potentially application in cosmetic industries.

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Author Biography

A. Gnanamani, Microbiology Division Central Leather Research Institute (CSIR-New Delhi) Adyar Chennai India

Dr. A. Gnanamani
Microbiology Division - Centrai Leather Research lnstitute
Adyar, Chennai 600020 - Tamil Nadu, India
Email: gnanamani3@gmail.com
Fax: 91-44-249112150

Published

2011-06-01

How to Cite

[1]
N. Radhakrishnan, V. Kavitha, STK. Raja, A. Gnanamani and A.B. Mandai 2011. Embelin-A natural potential cosmetic agent. Journal of Applied Cosmetology. 29, 2 (Jun. 2011), 99/107.