Non-Crosslinked Hyaluronic Acid Intralesional Therapy for Post-Mastectomy Scar Retraction and Pain: A Case Report

Abstract

Scars following mastectomy can lead to chronic pain, restricted mobility, and psychological distress. Intralesional injections with non-crosslinked hyaluronic acid (HA) may offer a minimally invasive solution to improve scar quality and function. A 56-year-old woman presented with a painful, retractile scar after right mastectomy with intraoperative radiotherapy. She experienced movement limitation and was considered a candidate for lipofilling. Two intralesional treatments were performed with Neauvia Hydro Deluxe (non-crosslinked HA + 0.01% CaHA). The patient reported improved tissue pliability, reduced pain, and enhanced mobility. Objective findings included improvements in the POSAS and reductions in pigmentation, vascularity, and scar thickness. The Global Aesthetic Improvement Scale (GAIS) rated the result as “very much improved.” This case highlights the potential of non-crosslinked HA for improving scar quality and reducing pain post-mastectomy, providing an alternative or adjunct to surgical revision.