Open-label uncontrolled, monocentric study for the evaluation of the efficacy and safety of mesotherapy using a solution of 0.1% hyaluronic acid, amino acid, and glutathione in the face

Abstract

  Aging research has focused on the accumulation of reactive oxygen species (ROS) over time, which are a main contributor to the aging process. The aim of the present study was to evaluate the efficacy and safety of the intradermal solution containing 0.1% HA, amino acids, and glutathione for the treatment of skin damage caused by free radicals. A total of 75 subjects were screened and analyzed, and 60 subjects were included in the study. Eligible subjects underwent baseline assessments and received 10 injections of solution of 0.1% HA, amino acid, and glutathione, one injection every 7 days for 8 weeks plus one injection every 15 days for four weeks. The efficacy of the treatments was evaluated by measuring the level of oxidative stress and GAIS at day 90. Photographic documentation of the treated regions was taken at all visits. The oxidative stress level had significantly improved at day 90 compared with the baseline as the mean at baseline was 477.4 while at day 90, it was 356.2. The GAIS improved significantly after 90 days, and the oxidative stress level significantly improved at day 90 compared to baseline as the mean at baseline was 477.4, while at day 90, it was 356.2. Based on the safety and efficacy data presented, SKIN OX is likely to be a valuable tool for treating skin damage due to free radicals and an asset to counter the effects of aging.