Rendu-Osler’s disease: the effectiveness of mixed technology laser  (Alexandrite laser combined with Nd:YAG laser)

Chiara Cozzi; R Mocchi; E D’Este; S Caravello; M Campoli; A Minuti; M Herrera; H Galadari; M Borodina; R Rauso; N Zerbinati

doi:10.56609/jac.v41i1.264

Authors

C. Cozzi Department of Medicine and Surgery University of Insubria (Varese) Italy/ Clinical Dermatology IRCCS Istituto Ortopedico Galeazzi Milan Italy
R. Mocchi UB-CARE S.r.l. Spin-off University of Pavia Italy
E. D’Este Dermatology Department Centro Medico Polispecialistico Pavia Italy
S. Caravello Dermatology Unit Ospedale di Circolo ASST Sette Laghi Varese Italy
M. Campoli Dermatology Unit Ospedale di Circolo ASST Sette Laghi Varese Italy/ Department of Medical Biotechnologies University of Siena Italy
A. Minuti Dermatology Unit Ospedale di Circolo ASST Sette Laghi Varese Italy
M. Herrera Centro Avanzado de Dermatologia y Laser San Pedro Sula 21104 Honduras
H. Galadari Department of Dermatology United Arab Emirates University Dubai United Arab Emirates
M. Borodina Pirogov Russian National Research Medical University of Moscow Moscow Russia
R. Rauso Maxillofacial Surgery Unit University of Campania “Luigi Vanvitelli” Naples Italy
N. Zerbinati Department of Medicine and Surgery University of Insubria (Varese) Italy

Keywords:

Rendu-Osler, Nd:YAG laser

Abstract

Rendu-Osler’s disease is an autosomal dominant disorder that usually affects the skin and mucous membranes, but also internal organs can be involved. To date, laser treatments have been used only to treat systemic lesions, while diathermocoagulation has been considered the primary treatment for skin lesions. We wished to evaluate the effectiveness of treatment with Alexandrite laser combined with Nd:YAG laser on vascular skin lesions of these patients. Vascular skin damage of 3 patients afflicted with Rendu-Osler’s disease was treated with Alexandrite laser combined with Nd laser:YAG laser. After 3 treatments, once a month, we found a remarkable improvement in skin lesions. The cutaneous manifestations of Rendu-Osler’s disease do not increase the mortality of these patients but are often the source of psychological discomfort. For this reason, it is necessary to have an effective treatment on hand and the Alexandrite laser combined with Nd:YAG laser represents an excellent therapeutic alternative to the diathermocoagulation.