Skin Quality and Aging: New Frontiers in Hydration, Firmness, and Cellular Regeneration

Abstract

 Skin aging involves a progressive decline in hydration, firmness, and regenerative capacity (1). The objective of this study is to evaluate the clinical effects and elucidate the mechanism of action of a novel biostimulator formulation composed of fragmented hyaluronic acid, choline, and essential amino acids on key indicators of skin quality, including hydration, dermal firmness, and cellular regeneration. The study further seeks to position this formulation as a low-inflammatory alternative to conventional aesthetic treatments that rely on controlled tissue damage, contributing to the development of biocompatible, physiologically integrative approaches in regenerative aesthetics. This study seeks to establish new therapeutic frontiers in aesthetic medicine, where biocompatibility, physiological biostimulation, and preservation of the cellular environment become pillars of healthy and conscious aging. Twenty patients aged between 35 and 65 years were treated over a 12-week period. Skin firmness was measured using cutaneous elastometry. Subjective and biometric evaluations were conducted. A 28% improvement in skin firmness was observed through elastometry (p<0.05). Patients reported significant improvements in hydration, tone, and luminosity. Biostimulatory solution for facial rejuvenation has illustrated the effect on physiological changes that mitigate facial aging.