Bioresorption of porous three-dimensional chi-tosan-based materials intended for use inmedical surgical cosmetology and tissue engi-neering

Abstract

Three-dimensional matrices with high porosity were prepared by lyophilization of chitosan solution.The mechanism and rate of resorption of the resulting materials were studied in vivo. It was shownthat resorption was completed in 12 months after implantation into an animal. The formation of con-nective tissue was not observed and the surrounding tissue had no signs of changes or damage.Histological analysis demonstrates that chitosan resorption occurred simultaneously with the forma-tion of collagen fibers and blood vessels. These results allow us to recommend the obtained chitosan-based porous material for use as a matrix for tissue engineering and medical cosmetology.