lchthyoses. Clinical, Biochemical, Pathogenic and Diagnostic Assessment

Abstract

This book, organized in 4 chapters and 3 append ices (chapter 5), differently from other books, looks from the functional abnormalities which drive the ichthyoses phenotype towards the responsible gene and not vice versa. Naturally, this new approach is most productive when the responsible gene is already known, also if the pathogenesis of the skin phenotype can mislead the investigator. On the contrary therapeutic interventions need to sustain and support the barrier restoration. Therefore while gene "replacement therapy sti li remains a distant dream'', a better "knowledge of cellular pathogenic mechanisms could provide immediate opportunities for nove! therapies" according with the opinion of the book's editors . Thus book is focused on the application of skin ultra structure to obtain a more sure diagnosis of different ichthyoses, utilizing a battery of techniques.