Adhesion and Arrest of Skin Microbes as Reason for Efficacy of a Pimple Cure Cream Paste (PCCP) – A Siddha Drug

Abstract

Pimple Cure Cream Paste (PCCP) was evaluated for its efficacy in controlling acne form eruptions (pimple) both by in vitro and in-use methods. The formulation contains the key herbal ingredients viz., Aloe vera and Ocimum basilicum, known for their activities. Result after single application of PCCP in facial skin and neck regions and vole forearms have shown the reduction in the abundance of key indicator colonies of Staphylococcus epidermidis. The re-colonization time of the organism was noted to be 8 hr. In order to ensure the fact that the activity is due to the adhesion of the drug on the skin. The treated and non treated areas were irradiated by UV, reading the erythema by the use of Mexameter. The PCCP was applied in the volar forearm region of the skin, allowed to dry for 10 minutes and then  the skin region was washed gently. The treated and non treated regions of the skin were exposed to sun for 15 minutes using a window patch made of light impermeable cloth. The findings show that the erythema readings were significantly lower in PCCP applied regions when compared to the control site. The findings confirm that even after washing, the drug shows remarkable residency (bioavailability) on the skin and thereby offers sun protection. Patients with type 1 and type 2 acne seeking medical advice, were given the drug (as prescription) and were instructed to use the above for a period of 6 weeks. Each patient was reviewed weekly. The findings of the study clearly show that in 3-4 week use of PCCP, the pimples were reduced. Besides controlling acne eruptions, also provided glow and improvement to the skin tone. This might be due to the possible sun protection effect coupled with moisturizing and skin lightening effects of the actives. The findings are discussed in the paper.