In vivo study of the nanofiber-based composite wound dressing intended for treatment of deep skin wounds

Authors

  • I. P. Dobrovolskaya Saint Petersburg State Polytechnic University Saint-Petersburg Russia Institute of Macromolecular Compounds RAS Saint Petersburg Russia
  • V. E. Yudin Saint Petersburg State Polytechnic University Saint-Petersburg Russia Institute of Macromolecular Compounds RAS Saint Petersburg Russia
  • P. V. Popryadukhin Saint Petersburg State Polytechnic University Saint-Petersburg Russia Institute of Macromolecular Compounds RAS Saint Petersburg Russia
  • I. O. Lebedeva Saint Petersburg State Polytechnic University Saint-Petersburg Russia
  • A. S. Shabunin Saint Petersburg State Polytechnic University Saint-Petersburg Russia
  • R. G. Stoyanovsky Saint Petersburg State Pediatric Medical University Saint Petersburg Russia
  • M. S. Asadulaev Saint Petersburg State Pediatric Medical University Saint Petersburg Russia
  • E. M. Ivan’kova Saint Petersburg State Polytechnic University Saint-Petersburg Russia Institute of Macromolecular Compounds RAS Saint Petersburg Russia
  • P. Morganti R&D Department Centre of Nanoscience MaviSud s.r.l

Keywords:

Aliphatic copolyamide, chitosan, chitin nanofibrils, electrospinning, wound dressing, Composite nanofiber

Abstract

Electrospinning technique was used for preparation of two-layer wound dressing consisting of a layerof aliphatic copolyamide nanofibers and a layer including chitosan nanofibers and chitin nanofibrils.Experimental studies (in vivotreatment of deep skin wounds with this dressing) demonstrated thatcomplete epithelialization of wound surface was achieved after 28 days. Histological analysis of scartissue indicated the presence of insignificant amount of capillaries and low amount of infiltrate cells.The survival of animals was 100%. At the same time, in the control group of animals, the lethalitywas observed in 10% of cases, and suppurative complications were observed in 100% of cases.

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Author Biography

V. E. Yudin, Saint Petersburg State Polytechnic University Saint-Petersburg Russia Institute of Macromolecular Compounds RAS Saint Petersburg Russia

Prof. Vladimir E.Yudin

Institute of Macromolecular Compounds

Russian Academy of Sciences

199004 St. Petersburg

V.O. Bolshoy pr., 31

phone: +7-812-3235065cell

E-mail: yudin@hq.macro.ru

Published

2016-06-01

How to Cite

[1]
I. P. Dobrovolskaya, V. E. Yudin, P. V. Popryadukhin, I. O. Lebedeva, A. S. Shabunin, R. G. Stoyanovsky, M. S. Asadulaev, E. M. Ivan’kova and P. Morganti 2016. In vivo study of the nanofiber-based composite wound dressing intended for treatment of deep skin wounds. Journal of Applied Cosmetology. 34, 1/2 (Jun. 2016), 1/8.

Issue

Vol. 34 No. 1/2 (2016): Journal of Applied Cosmetology

Section

EVALUATION STUDY
Copyright & Licensing

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